Healthy Longevity ClinicHealthy Longevity Science
Editorial approach
Healthy Longevity Clinic

Science, with perspective.

Explore the questions behind healthy longevity. Understand the evidence, its possibilities and its limits.

72 articles

A blank notebook and pencil sit in front of paper sculptures suggesting muscle fibers, a brain and a rounded immune-biology form.HLC research & XPRIZE

HLC’s XPRIZE research: pilot findings and the next questions

Healthy aging becomes tangible when it means walking more easily, maintaining strength and staying independent. Our eight-week Prague pilot brought coordinated care and repeat measurement together in ten older adults, with encouraging changes in mobility and blood-sugar regulation. Alongside this work, our collaboration with Klothea Bio explores a new biological approach through Klotho. Both are part of a wider effort to turn longevity science into more years of useful function.

Healthy Longevity Science6 min read
Four sealed blood-sample tubes in a rack, with a clear empty multiwell plate and a closed teal notebook.Blood and plasma therapies

Plasma exchange and aging clocks: what the human trial found

Could changing the proteins circulating in our blood influence aging? Plasma-exchange research is exploring that possibility. A small human study found encouraging changes in some biological-age measurements partway through treatment, raising new questions about how the procedure affects the body. To understand the finding, it helps to know what an aging clock measures, why the treatment combination matters, and what researchers still need to learn about lasting health benefits.

Healthy Longevity Science5 min read
A clear droplet-shaped glass sculpture contains red concave discs and pale round forms on a warm neutral background.Blood & plasma research

Blood and plasma treatments: what the evidence supports

Plasma is a busy part of the body: it carries proteins, immune signals and other substances between tissues. Changing what circulates in it can be a powerful medical tool, and researchers are now exploring applications in healthy aging. From lowering certain pollutants to studying plasma-derived signals, the field offers several different ideas. Understanding what each procedure removes or adds is the key to understanding its promise.

Healthy Longevity Science6 min read
A rhesus macaque with brown-gray fur and a pink face sits quietly against a pale neutral background.Klotho & translational research

Klotho: promising animal results, early human research

Klotho is a protein our bodies already make, and it has become one of the most intriguing leads in aging research. Studies in older animals suggest that it can influence memory, physical function and, in some circumstances, lifespan. The next step is to understand how to use that biology safely in people. We explain what makes Klotho interesting, how the different treatment approaches work, and why Healthy Longevity Clinic is involved in this research.

Healthy Longevity Science6 min read
A white rat beside three sealed tubes of pale fluid, separated by a transparent partition.Blood and plasma therapies

Young plasma and E5: what the rat studies actually show

Blood carries much more than oxygen and nutrients. Its liquid component, plasma, contains signals that help tissues communicate—and some may influence how we age. E5 research explores whether selected components from young pigs’ plasma can support healthier aging. Small rat studies have reported encouraging changes in function, molecular age and lifespan. The challenge now is to understand what drives those effects and whether they can become a useful treatment for people.

Healthy Longevity Science5 min read
A middle-aged woman and a gray-muzzled companion dog sit together on a garden bench.Translational longevity research

What dog longevity research can tell us about healthy aging

A longer life means more when it includes more good years: walks, play, curiosity and companionship. Dogs may help us understand how to preserve those years. Research ranging from LeapYears supplements to gene therapy is exploring ways to support the aging brain and body, while larger trials ask whether treatments can help dogs live longer. The discoveries matter for our pets—and may also open new paths in human medicine.

Healthy Longevity Science6 min read
A translucent pale teal spherical shell is cut away to reveal several abstract rust and ivory shapes inside.Exosomes & extracellular vesicles

Exosomes: research, marketed products and regulatory status

Cells communicate partly through tiny packages that carry biological cargo. Exosome research asks whether we can turn that communication system into useful treatments. Early human studies offer some encouraging skin findings, alongside disappointing results elsewhere. Understanding the promise starts with a simple point: the contents of the package, and where it is delivered, matter.

Healthy Longevity Science5 min read
An empty clear culture dish and its tilted lid lie across two closed blank folios under palm-leaf shadows.Stem-cell evidence & regulation

Florida stem-cell rules: state provisions and federal requirements

The appeal of stem-cell treatment is easy to understand: help damaged tissue recover, reduce pain and restore movement. Florida’s rules have brought renewed attention to that possibility by allowing certain uses under state conditions. To make sense of an offer, it helps to connect three things—the exact cell product, the rules governing it and the health improvement its studies actually support.

Healthy Longevity Science5 min read
Two translucent blank sheets lie on a closed teal folio in front of an imagined mountain-and-prairie view.Experimental treatment regulation

Montana’s experimental treatment centers: what the rules require

Montana is testing a new approach to experimental medicine: licensed centers where certain investigational treatments can be considered under state rules. The framework reaches beyond the patient criteria of federal right to try and sets requirements for clinical review, consent and follow-up. Its promise depends on how those responsibilities work in practice—and on the evidence for each treatment.

Healthy Longevity Science5 min read
A terracotta heart sculpture stands beside an unlabeled sample tube held upright in a small ivory holder.Cardiovascular prevention

High Lp(a): what the HORIZON report means for prevention

Some cardiovascular risk is inherited, and lipoprotein(a), or Lp(a), can reveal a part that routine cholesterol tests miss. Knowing your level can help shape prevention even while new treatments are being tested. The first major HORIZON result was disappointing: lowering Lp(a) with pelacarsen did not establish the hoped-for reduction in serious events. Here is what that finding means for the science—and what a high result can still help you do today.

Healthy Longevity Science4 min read
A woman with gray-streaked hair and reading glasses sits by a window holding a folded cream leaflet.Hormones and midlife health

Menopause hormone therapy: what the FDA label changes mean

Hot flashes, night sweats and vaginal discomfort can make midlife unnecessarily difficult. Hormone therapy can offer meaningful relief, and revised US warnings are helping bring the conversation back to the individual woman. The choice depends on her symptoms, health history and the type of treatment. We explain what changed, why timing and route matter, and what research says about the wider hopes for heart, brain and long-term health.

Healthy Longevity Science5 min read
Seen from above, a magnifying glass rests on blank open folios between two partly visible hands.Supplements and healthy aging

Taurine and aging: what changed after the mouse study

A familiar molecule became a major longevity story when taurine helped mice live longer. The finding opened an appealing possibility: could something our bodies already make help preserve health with age? Later research has made the story more interesting—and more complicated. Blood taurine does not simply fall as everyone gets older, and human trials are now testing which benefits, if any, supplementation can deliver.

Healthy Longevity Science5 min read
A clear unlabeled fluid bag with two capped ports hangs from a simple hook on an ivory background.NAD & cellular energy

NAD infusions: what the human studies show

NAD helps cells turn nutrients into usable energy, which makes it a compelling target for research into aging and disease. Scientists are testing whether giving it by infusion can improve health. An encouraging heart-failure study offers one clue; smaller studies explain what happens during a drip. Together, they show where the idea is promising and why benefits for everyday energy, memory and healthy aging still need direct testing.

Healthy Longevity Science5 min read
Blood and plasma therapies

Therapeutic plasma exchange: changes over time and biological-age research

Healthy Longevity Clinic’s longitudinal follow-up recorded LDL cholesterol falling from 165 to 64 mg/dL before the fifth therapeutic plasma exchange (TPE) session. A second report tracked metals, BPA, pesticide metabolites, mycotoxins and PFAS over three months. A controlled 2025 study adds biological-age findings, including a 2.61-year reduction with TPE plus IVIG at its intermediate assessment.

Healthy Longevity Science5 min read
A man with gray hair begins to rise from an armless wooden chair in a sunlit room.Peptides

Growth-hormone stimulators: higher levels, mixed benefits

MK-677, CJC-1295, ipamorelin, sermorelin and capromorelin differ in their evidence for strength, mobility and cognition. In a 65-person trial, MK-677 increased fat-free mass without improving strength or function, while blood glucose rose. Other studies found narrower benefits. Healthy Longevity Clinic examines which results could support independence, and where hormonal changes leave the clinical question unanswered.

Healthy Longevity Science6 min read
A simplified side cutaway of an eye, with a curved inner retinal layer and an optic nerve extending from the back.Frontiers of longevity

Partial reprogramming: what the eye trial can tell us

Partial reprogramming has reached human testing. ER-100’s sponsor announced first dosing in June 2026, in an eye-disease study planning 18 adults. The trial asks first about safety; whether it improves useful vision remains unanswered. Mouse experiments provide a scientific rationale, but the human evidence dated September 21, 2026 contains no reported outcomes showing restored sight or broader rejuvenation.

Healthy Longevity Science10 min read
A woman in sports clothes reads a plain booklet while seated on a bench beside a running track.Peptides

Peptides and sport: what the rules require

BPC-157 is prohibited in and out of competition under the 2026 World Anti-Doping Agency (WADA) list. That matters for amateurs as well as professionals when their sport applies those rules. A prescription does not create an exemption, and the US Anti-Doping Agency (USADA) calls a BPC-157 exemption unlikely, not impossible. Start with your governing authority, the exact substance, and the medical reason for treatment.

Healthy Longevity Science10 min read
Two middle-aged adults sit at a table and discuss blank report pages beside a notebook and pencil.Measuring aging

Which aging tests can help you make a better health decision?

Blood pressure, selected blood tests and fitness assessments can help guide useful health decisions. Biological-age clocks answer a different question: they estimate patterns linked to aging, without showing that treating the score improves health. No established test can precisely count your remaining healthy years. Before paying for an aging assessment, ask what a result would change about your care.

Healthy Longevity Science9 min read
Two magnifying lenses on blue stands show different magnifications of one terracotta pebble.Measuring aging

Why biological-age tests give different answers

Biological-age tests can disagree because they measure different features of aging and compare you with different reference groups. A repeat test can also change without showing a lasting health change. In a 2026 analysis of 18 DNA-based aging measures, many were more consistent when the same sample was measured again than when fresh samples were collected. That distinction matters when interpreting your own result.

Healthy Longevity Science10 min read
Two plain cups and small unmarked tablets sit on separate blank cards, with a notebook and magnifying glass behind them.Medicines and longevity

Rapamycin and aging: what human trials tell us

Rapamycin (sirolimus) has mixed human evidence for healthy aging. PEARL found no improvement in its main body-fat measure over 48 weeks, and RAPA-EX-01 found no added functional benefit alongside exercise. Everolimus improved selected vaccine responses, while a larger RTB101 trial missed its respiratory-illness endpoint. Healthy Longevity Clinic weighs these results by function, infection prevention and tolerability.

Healthy Longevity Science10 min read
A gray-brown macaque sits upright on a leafy branch against a pale background.Medicines and longevity

Metformin for healthy aging: what the evidence supports

Metformin helps control type 2 diabetes and reduced new diabetes cases by 31% relative to placebo in the Diabetes Prevention Program. That is a meaningful healthspan benefit for people at high risk. This review distinguishes established prevention from newer frailty findings, exercise trade-offs and the proposed TAME trial, which aims to test broader prevention of age-related disease.

Healthy Longevity Science11 min read
An empty MRI scanner is visible through glass behind two chairs and a table holding a closed folder.Measuring aging

Whole-body MRI: what it finds and what follows

Whole-body MRI can discover an unsuspected cancer or another important abnormality. A review of ten studies involving 9,024 people without symptoms estimated roughly 16 confirmed cancers per 1,000 people screened. That is detection, not a count of lives saved. Scans can also trigger further tests for uncertain findings, and longer life from routine screening of well, average-risk adults has not been established.

Healthy Longevity Science9 min read
A gray-haired man in a loose green shirt walks up stone steps in a leafy park.Medicines and longevity

GLP-1 medicines: benefits beyond weight loss

Semaglutide has shown benefits beyond weight loss. In SELECT, serious cardiovascular events occurred in 6.5% of treated adults versus 8.0% with placebo; participants had cardiovascular disease and overweight or obesity, without diabetes. Kidney and symptom benefits in other defined groups add to the healthspan picture. Healthy Longevity Clinic examines who benefited, how much, and which risks affect the decision.

Healthy Longevity Science12 min read
Three broad paper ribbons in sage, terracotta and cream curl upward together on a pale surface.Medicines and longevity

Retatrutide: what the weight-loss trials show

Retatrutide has produced substantial weight loss in clinical trials. In one phase 3 study, Lilly reported an average reduction of 28.7% versus 2.1% with placebo over 68 weeks in an analysis assuming continued treatment. Published research also shows improved glucose control in type 2 diabetes. These benefits warrant attention, but cardiovascular protection, long-term safety and an approval date remain unsettled.

Healthy Longevity Science10 min read
Six rounded, layered paper forms with central disks cluster on an ivory background in sage, cream and terracotta.Medicines and longevity

Senolytics in humans: what the trials show

Dasatinib–quercetin, fisetin and the experimental drugs UBX0101 and UBX1325 test whether removing senescent cells can improve bone, lung, joint or eye health. Results are mixed: several trials missed their main goals, while narrower biological and visual signals warrant follow-up. Healthy Longevity Clinic compares the prospects for fewer fractures, better mobility and preserved vision, together with treatment risks.

Healthy Longevity Science10 min read
An ivory paper sculpture in the shape of a brain stands on a plinth beside a closed folder on a blue tabletop.Measuring aging

Brain MRI measurements: how to read the report

BrainKey and NeuroQuant turn brain MRI scans into measurements that can inform assessment of memory and thinking problems. They measure different features and require interpretation alongside symptoms and cognitive tests. Healthy Longevity Clinic explains brain volume, percentiles and “brain age,” showing which findings can support a care decision and why a low percentile alone is not a dementia diagnosis.

Healthy Longevity Science11 min read
An optical microscope beside an empty glass culture dish and a closed notebook on a softly lit bench.Frontiers of longevity

Longevity research: what has reached human trials?

ER-100 reprogramming, telomerase mRNA, SIRT6, TRIIM thymus regeneration, senolytics, mitochondrial transplantation, cholesterol degradation, Klotho mRNA and plasma fractions target different aspects of age-related decline. This September 2026 overview compares all nine approaches, their human or preclinical evidence, and the next useful outcomes: preserved vision, stronger immunity, tissue recovery and fewer serious illnesses. Healthy Longevity Clinic explains which developments merit attention.

Healthy Longevity Science11 min read
A textured X-shaped model of a replicated chromosome, with four rounded end regions in muted terracotta.Frontiers of longevity

Telomerase mRNA: a promising cell result, an open clinical question

Telomerase mRNA lengthened telomeres by up to about 900 DNA building blocks in cultured human cells in a 2015 experiment. Rejuvenation Technologies is developing this approach for impaired tissue maintenance, including fibrosis. Healthy Longevity Clinic examines the potential for tissue repair, the gap between cell results and patient outcomes, and why delivery and long-term safety are central to clinical progress.

Healthy Longevity Science10 min read
A painted close-up of a hazel eye shows the eyelids, eyebrow and natural lines in the surrounding skin.Measuring health

What can an eye measurement tell you about health?

Occuity PM1 measures corneal thickness; its Indigo and SD1 programs explore glucose measurement and diabetes-risk screening. These uses differ from LumineticsCore, which has a defined US authorization for diabetic retinopathy screening. Healthy Longevity Clinic compares the evidence for each approach and explains when an eye measurement could guide follow-up, protect vision or support a more informed health decision.

Healthy Longevity Science10 min read
A translucent, irregularly shaped cell illustration with a rounded nucleus and fine internal strands.Frontiers of longevity

Senescent cells: remove them or change their behavior?

SENISCA is developing RNA-splicing approaches to change how senescent cells behave, with programs in lung fibrosis and skin health. Laboratory studies show that selected cell functions can recover, although DNA damage and other responses do not always improve together. Healthy Longevity Clinic compares this strategy with senolytics and asks whether it could preserve tissue function without unsafe cell growth.

Healthy Longevity Science9 min read
A simplified muscle bundle with a cutaway at one end showing groups of parallel fibers.Frontiers of longevity

Protecting muscle during weight-loss treatment

Semaglutide and tirzepatide can reduce lean tissue as well as fat. Exercise and adequate nutrition help make strength and independence central to weight-loss care. Bimagrumab has human body-composition results; MitoRx’s MTRX31 and Juvena’s JUV-161 explore further muscle-preserving approaches at earlier stages. Healthy Longevity Clinic compares what the findings mean for physical function, beyond a lower number on the scale.

Healthy Longevity Science11 min read
A simplified terracotta-colored liver model on a pale textured background.Frontiers of longevity

Cholesterol degradation: can it shrink artery plaque?

Artery plaque can shrink. Established cholesterol-lowering treatment reduces cardiovascular events and has produced modest plaque shrinkage in human imaging trials. Repair Biotechnologies is investigating a different approach: helping liver cells process excess cholesterol. Its mouse findings support further research, but do not establish how much human plaque would shrink, whether heart attacks would fall, or whether the treatment is safe in people.

Healthy Longevity Science10 min read
An oval mitochondrion model cut open to show folds of its inner membrane.Frontiers of longevity

Mitochondrial transplantation: human studies and Mitrix Bio

Mitochondrial transplantation has produced encouraging early heart-recovery findings. In one small comparison, 8 of 10 treated children came off heart-lung support for at least a week, versus 4 of 14 controls. Mitrix Bio is developing separate infusion and bioreactor programs. Healthy Longevity Clinic examines the prospects for recovery, physical capacity and independence, and the evidence each approach still needs.

Healthy Longevity Science10 min read
Two women sit beside an open book with blank pages, one pointing to a page while the other listens.Medicines and longevity

Longevity drugs: what human trials show

Metformin, semaglutide and dapagliflozin reduce diabetes or serious heart and kidney events in defined patient groups. Evidence for rapamycin (sirolimus), the senolytic combination dasatinib–quercetin and the NAD precursor nicotinamide riboside (NR) remains early or mixed. This September 2026 overview also compares testosterone and menopausal hormone therapy. Healthy Longevity Clinic assesses their healthspan value through disease prevention, physical function and symptom relief.

Healthy Longevity Science14 min read
Healthy Longevity SciencePublished by Healthy Longevity ClinicEditorial approachCorrectionsResearch in context. Discuss personal medical decisions with your clinician.